Combined resection for multifocal lesions of the pancreas.

BACKGROUND/AIMS Multifocal lesions of the pancreas generally require a total pancreatectomy. However, total pancreatectomy causes severe and permanent pancreatic endocrine and exocrine insufficiency. The aim of this study was to review our experiences of combined resection of the pancreas as an alternative to total pancreatectomy. METHODOLOGY From July 2004 to July 2011, 5 patients were indicated to undergo combined resection for multiple lesions of the pancreas at our institution. RESULTS The surgical procedures for combined resection of the pancreas in the 5 patients consisted of various limited resections of the pancreas. No patient developed insulin-dependent diabetes mellitus. In addition, no patient developed exocrine insufficiency after pancreatic resection. CONCLUSIONS For multifocal lesions of the pancreas, combined resection of the pancreas should be considered the surgical procedure of choice to reduce the risk of both endocrine and exocrine insufficiency.